Site-Directed Nuclease (SDN)

SDN or sequence specific nuclease (SSN) refers to the practice of cleaving DNA strands to affect the subsequent genome editing.

  • SDN technology takes advantage of targeted DNA break and host’s natural repair mechanisms to introduce specific small changes at the site of the DNA break.
  • Main SDN technologies includes Zinc-Finger Nucleases (ZFNs) and Transcription Activator Like Effector Nucleases (TALENs).
  • Depending on the nature of the edit, the process is divided into three categories — SDN 1, SDN 2 and SDN 3.
  • Both SDN1 and SDN 2 do not involve alien genetic material and the result is indistinguishable ....
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