Self-amplifying mRNA Vaccine

  • A self-amplifying mRNA vaccine (ARCT-154), in which the delivered RNA multiplies inside the body, has shown promising results against COVID-19 in ongoing trials.
  • It offered 95% protection against severe COVID-19 and death, and 55% protection against COVID-19 infection.
  • The mRNA directs the cell to produce copies of the spike protein so that the immune system will recognise the spike if and when actual infection occurs, and mount a response.
  • It encodes four extra proteins in addition to the vaccine antigen, and these enable amplification of the original strand of RNA once inside the ....
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