Pangenome Reference Map

On May 10, 2023, a new study was published which described a pangenome reference map, built using genomes from 47 anonymous individuals (19 men and 28 women), mainly from Africa but also from the Caribbean, Americas, East Asia, and Europe.

Key Points

  • About Pangenome Reference Map: It provides a more comprehensive understanding of human genetic diversity. It contrasts the linear structure of traditional reference genome.
  • Forms of a Graph: Pangenome map takes the form of a graph. Chromosomes in the graph feature nodes where sequences from all 47 individuals converge.
  • Internodes represent genetic variations among individuals from different ancestral backgrounds. Long-read ....
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