CCR5 Mutation

  • Recently, a patient from Germany has become at least the third person to have been cured of HIV with bone-marrow transplant from people carrying a specific HIV-resistant genetic mutation (CCR5-Delta32 mutation).
  • HIV (Human Immunodeficiency Virus) mainly attacks the CD4 immune cells in the human body, thereby reducing a person’s ability to fight off secondary infections.
  • The CCR5 receptors on the surface of the CD4 immune cells act as a doorway for the HIV virus.
  • However, the CCR5-Delta32 mutation prevents these receptors used by the HIV virus from forming on the surface, effectively removing the ....
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