Controlled Human Infection Studies

  • The Indian Council of Medical Research (ICMR) has embarked on introducing Controlled Human Infection Studies (CHIS).
  • CHIS is also called human challenge studies, where healthy volunteers are intentionally exposed to a disease-causing microbe in a highly controlled and monitored environment.
  • It has been carried out for hundreds of years.
  • Example: The yellow fever study in the early 1900s to establish that mosquitoes transmit the virus.
  • It holds the promise of accelerating vaccine and treatment development for infectious ....
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