Self-amplifying Messenger RNA (mRNA) Vaccine

Unlike conventional vaccines that inject a weakened form of a virus or bacteria into the body, RNA vaccines use part of virus’ own genes to stimulate an immune response.

  • A conventional mRNA vaccine, such as those from Pfizer and Moderna, uses mRNA that encodes the spike protein of the coronavirus.
  • mRNA vaccines teach cells how to make copies of the spike protein that triggers an immune response inside human bodies, when actual infection takes place.
  • A self-amplifying mRNA vaccine is an improvement over the traditional mRNA as it encodes four extra proteins in addition to the vaccine antigen, ....
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